Registration Number
0218U006942,
0117U002580
, R & D reports
Title
Early molecular genetic and immunohistochemical predicting of susceptibility to lung and digestive system cancer progression.
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Head
Tumanskiy Valeriі Оleksііоvуch,
Registration Date
23-10-2018
Organization
Zaporozhye State Medical University
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It was identified, that decrease of transcriptional activity of CDH1 - gene and E-cadherin expression, and elevation of activity of CTNNB1 - gene and b-catenin expression in tumor cells play important role in progression of intestinal type stomach adenocarcinoma; has been proven that increase EGFR and HER2/neu receptors expression in adenocarcinomas cells leads to the activation of transcription and translation K-RAS - gene with further activation of ERK - signaling cascade, that realizes proliferative potential of tumor cells. It was discovered, that hyperplastic stomach polyps and intestinal type stomach adenocarcinomas differ in levels of expression of mucins that has prognostic value. It has been established that tumor cells of colorectal adenocarcinoma are characterized by mean proliferation, mean p53 expression and low apoptosis, whereas cells of the microenvironment of this tumor are characterized by low levels of proliferation, expression of p53 and apoptosis; there was found direct strong correlation between the parameters of proliferation and apoptosis of cancer cells, as well as vs; tumor microenvironment cells have similar features.It has been found out that in the highly differentiated adenocarcinoma of the pancreas, neoplastic ductular large and small glandular structures resembling ducts or crinkle structures that are unevenly located in abundant sclerotized stroma with a desmoplastic reaction are predominantly detected. A statistically significant difference was found between the specific density of CD68 + cell infiltration in the stromal component in the squamous lung cancer, in particular in the intratumorous stromal zone (p = 0.004), as well as in the tumor complexes (p = 0.002). It was found that in patients with expressive immune-cellular infiltration in the immunocyte follicular infiltrates in the polyps stroma of the maxillary sinus, the relative area of CD4 + and CD8 + T lymphocytes statistically significantly exceeds the relative area of macrophages and plasma cells.
Product Description
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Баударбекова М.М
Коваленко І.С.
Христенко Т.О.
Шишкін М.А.
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2020-04-02
