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Information × Registration Number 0218U007158, 0118U006044 , R & D reports Title Molecular design and development of rational methods of (thia)calix[4]arenes functionalization which regulate hydrophilic-lipophilic balance and decrease their toxicity popup.stage_title Head Rodik Roman Vasylevych, Кандидат хімічних наук Registration Date 20-12-2018 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 Due to the previously developed method of regioselective alkylation of the macrocycle's lower rim of the tetranitrothiakaliks[4]arenes, the tetrasulfonylamidinoathiacalix[4]arenes were synthesized for the first time. The change in the length of the alkyl substituents varies with the hydrophilic-lipophilic balance of the molecules. A method of synthesis of bis-dansylamidocalix[4]arene with fluorophoric groups on the upper rim is developed. It is shown that its fluorescence practically doesn't depend on the solvent type and has a high quantum yield. It is promising for the study of the inhibition of the inhibition of the Ca2+,Mg2+-ATPase of smooth muscle cells by sulfonylamidine calix[4]arenes and the determination of the role of the hydrophilic-lipophilic balance in this process. The method of one-stage conjugation of tetraaminocalixarenes and known drugs: ibuprofen and analbenne have been developed. The analben conjugate exhibits significantly more analgesic and decongestant effects than analbene itself. The results can be implemented in physico-chemical research, biochemistry and medical research. Product Description popup.authors Денисенко Ольга Миколаївна Довгоп'ята Лідія Соловеївна Допіра Тетяна Іванівна Драпайло Андрій Богданович Лісова Ганна Олексіївна Родік Роман Васильович Роженко Олександр Борисович Святненко Ганна Степанівна popup.nrat_date 2020-04-02 Close