Registration Number
0218U007834,
0113U007276
, R & D reports
Title
Exploration of the role of mitochondria in responses of cardiovascular system at different functional states of an organism
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Head
Sagach Vadym Fedorovych,
Registration Date
20-12-2018
Organization
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine
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It was found that inhibition of the synthesis of hydrogen sulfide (H2S) formed by the mitochondrial enzyme 3-mercaptopyruvatesulfurstransferase (3-MST) reduces the resistance of the myocardium to calcium loads, enhances the Ca2+-induced pore-dependent swelling of cardiac mitochondria , and stimulation of H2S synthesis has a stabilizing effect on mitochondria membranes and restores endothelium-dependent relaxation of blood vessels of old animals. It was established a tight relationships between the H2S system, glutathione and nitric oxide (NO), which play an important role in the formation of the membrane potential of mitochondria and myocardial reserves, in particular, in ischemia-reperfusion, and also in Parkinson's disease and diabetes mellitus, in which significant violations are established not only in peripheral (reduction of endothelium-dependent relaxation of vessels), but also in the central structures of the brain regulating vascular tone and systemic arterial pressure. It has been shown that physiological disorders associated with a decrease in NO synthesis can be reduced by endothelial monocyte activating polyprotein (EMAPII). The features of calcium channels in the endothelium with genetically determined atherosclerosis and potassium channels of mitochondria as the main mediators of the protective signaling pathways were also studied.
Product Description
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І.Ю.Охай
А.І.Бондаренко
А.Ю.Лучкова
Б.С. Коп"як
В.Ф. Сагач
К.О.Драчук
Л.А.Мись
Л.М. Шаповал
Н.А. Струтинська
Н.О. Дорофєєва
О.В. Акопова
О.В.Дмитренко
Р.А.Федічкіна
Т.А. Ільїна
Ю.В.Гошовська
Ю.П.Коркач
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2020-04-02
