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Information × Registration Number 0219U000003, 0115U001379 , R & D reports Title Peculiarities of "Ferroplat" interaction with structural and functional components of sensitive and resistant tumor cells popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 03-01-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 It was shown that Feroplat causes structural and functional impairment of the cell membranes in the cells of high-malignancy by reducing the content of cholesterol by 25-32% and increasing the ratio of "phosphatidylcholine / sphingomyelin" (FX / SM) to 2.0-2.7 times. In cells of low malignancy degree (MCF-7, T47D) only a decrease in the level of cholesterol (by 17-23%) was observed after Feroplat treatment. Similarly, Feroplat affected the plasma membrane of sensitive, and especially drug-resistant carcinosarcoma Walker-256 cells. The content of cholesterol in membranes of sensitive cells decreased by 30%, whereas in resistant cells - by 39% (p <0.05). It was also found that the content of cardiolipin in mitochondria under the action of Feoplat decreased by 1.2-1.5 times (p <0.05). At the same time, the effect of Feroplat was more pronounced in cells of high malignancy degree and with the phenotype of drug resistance. Therefore, Feroplat can cause structural and functional impairment of cell membranes of breast cancer cells. The effect of Feroplat on the membrane was more pronounced in cells of high malignancy degree and with the phenotype of drug resistance. The mentioned changes indicate an increase in the fluidity of the membranes, and hence to increase their permeability under the influence of Feroplat. Product Description popup.authors Борікун Тетяна Вікторівна Горбик Дарья Миколаївна Задворний Тарас Володимирович Лук'янова Наталія Юріївна Петрановська Алла Леонідівна Тодор Ігор Миколайович Чехун Василь Федорович Швець Юлія Вікторівна Яловенко Тетяна Миколаївна popup.nrat_date 2020-04-02 Close