Registration Number
0219U000003,
0115U001379
, R & D reports
Title
Peculiarities of "Ferroplat" interaction with structural and functional components of sensitive and resistant tumor cells
popup.stage_title
Head
Chekhun Vasyl Fedorovych,
Registration Date
03-01-2019
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
popup.description2
It was shown that Feroplat causes structural and functional impairment of the cell membranes in the cells of high-malignancy by reducing the content of cholesterol by 25-32% and increasing the ratio of "phosphatidylcholine / sphingomyelin" (FX / SM) to 2.0-2.7 times. In cells of low malignancy degree (MCF-7, T47D) only a decrease in the level of cholesterol (by 17-23%) was observed after Feroplat treatment. Similarly, Feroplat affected the plasma membrane of sensitive, and especially drug-resistant carcinosarcoma Walker-256 cells. The content of cholesterol in membranes of sensitive cells decreased by 30%, whereas in resistant cells - by 39% (p <0.05). It was also found that the content of cardiolipin in mitochondria under the action of Feoplat decreased by 1.2-1.5 times (p <0.05). At the same time, the effect of Feroplat was more pronounced in cells of high malignancy degree and with the phenotype of drug resistance. Therefore, Feroplat can cause structural and functional impairment of cell membranes of breast cancer cells. The effect of Feroplat on the membrane was more pronounced in cells of high malignancy degree and with the phenotype of drug resistance. The mentioned changes indicate an increase in the fluidity of the membranes, and hence to increase their permeability under the influence of Feroplat.
Product Description
popup.authors
Борікун Тетяна Вікторівна
Горбик Дарья Миколаївна
Задворний Тарас Володимирович
Лук'янова Наталія Юріївна
Петрановська Алла Леонідівна
Тодор Ігор Миколайович
Чехун Василь Федорович
Швець Юлія Вікторівна
Яловенко Тетяна Миколаївна
popup.nrat_date
2020-04-02
