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Information × Registration Number 0219U000186, 0116U001031 , R & D reports Title Investigate polymodal evoked potentials of the brain, including cognitive, in patients with chronic ischemia of vertebral-basilar pool, depending on violations of blood supply to the brain popup.stage_title Head Chebotariova Lidija, Registration Date 18-01-2019 Organization Academician A.Romodanov Institute of neurosurgery AMSc of Ukraine popup.description2 Abstract. 70 p., 26 dr., 18 tab., 25 sour. Objective.To evaluate the effectiveness of brain evoked potentials for the objectivization of early cognitive disorders (CD) induced by cerebral and regional hypoperfusion. Materials and methods. The influence of hypoperfusion in vertebrobasilar territory (VBT) on characteristics of cognitive functions in 52 patients with chronic brain ischemia was studied. The following methods were used: cliniconeurological, MRI, SPECT, duplex ultrasound scanning (DUS), EEG, and brain evoked potentials (EP). Results.The patients were split into two groups by DUS scan findings: 1 - those having structural lesions in vertebral arteries (VA), and haemodynamically significant disorders in VBT and 2 - those having none. The examination of patients of the 1st group showed the following findings: high frequency of blood flow velocity decrease in VA; the tendency of decreasing in volumetric cerebral blood flow in brain segments and hemispheres according to SPECT data; prevalence of ataxia, coordination and long tract signs; high frequency of early CD in the domains of attention and memory; EP index changes. The patients with blood flow decompensation in VBT (according to DUS findings) showed changes in brainstem auditory EP parameters (BAEP): increase of III, IV, V latency peaks and III-V interpeak interval. According to the cognitive EP (CEP) study, the patients of the 1st group consistently demonstrated higher frequency of N2 peak amplitude decrease, and P300 peak latency increase. Conclusions. Based on DUS scan findings, it is clinically appropriate to distinguish a group of patients with structural and haemodynamically significant disorders in VA. The deviations from the normal indices of CEP and BAEP correlate with CD occurring as a result of cerebral and regional hypoperfusion in VBT. Key words: chronic brain ischaemia; vertebrobasilar territory; cognitive disorders; brain evoked potentials; ultrasound duplex scanning. Product Description popup.authors Ващенко В. В. Глоба М. В. Міхаль Г. В. Макеєв С. С. Николов М, А. Новікова Т. Г. Солонович О. С. Сулій Л. М. Третьякова А. І. Чеботарьова Л. Л. popup.nrat_date 2020-04-02 Close