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Information × Registration Number 0219U000187, 0116U001033 , R & D reports Title To develop combined methods of treating patients with metastatic tumors of the subtentorial localization popup.stage_title Head Zozulya Yuriy Panasovych, Registration Date 18-01-2019 Organization Academician A.Romodanov Institute of neurosurgery AMSc of Ukraine popup.description2 Objective. To determine the indications for surgical intervention and treatment tactic for metastatic infratentorial tumors. Materials and methods. The study included 162 patients with metastatic tumors of the subtentorial localization treated from 1995 to 2018. 102 patients (79.7%) underwent total removal by the perifocal zone of tumor growth, 9 (7%) - subtotal and 8 (6.3%) - partial. In 5 (3.9%) patients tumor removal was combined by a CSF-shunting; in 4 (3.1%) cases, surgical assistance was limited to the installation of a CSF-shunt system. Results. The most frequent sources of metastasis to the posterior cranial fossa were lungs - 42 (32.8%) patients, the mammary gland - 19 (14.8%) and melanoma - 15 (11.7%). A separate large group consisted of patients with unknown primary focus (32 patients (25%)). Among the 43 patients with known catamnesis there were 37(86%) patients with solitary metastases were and with multiple (including supra-infratentorial) - 6 (14%). The average survival after surgery in patients with solitary metastases was 8.4 ± 1.5 months, with multiple (including sub-supratentorial) 5.1.1 0.8 months. Survival of more than 1 year was observed in 13 (30.2%) patients (of which 1 (2.3%) - with multiple metastases). Conclusions: Patients with infratentorial metastases as well as with multiple metastatic brain lesions should be considered for surgery even if KPS<70 especially due to CSF obstruction. Posterior fossa decompression with CSF flow restoration lead to survival prolongation, patients condition improvement and gives possibility for further radiotherapy, chemotherapy or radiosurgery. Product Description popup.authors А.Б. Грязов В.А. Яцик В.В. Гудков В.О. Федірко Д.В. Кубряк Д.М. Цюрупа Д.С. Тесленко К.О. Робак Л.В. Задояний М.І. Лісяний О.В. Земскова О.М. Лісяний О.Ю. Чувашова О.Я. Главацький П.М. Оніщенко Т.А. Малишева popup.nrat_date 2020-04-02 Close