Registration Number
0219U000473,
0116U004574
, R & D reports
Title
Modeling of nanostructural environmental systems of decontamination of phosphororganic toxic substances.
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Head
Volodymyr Bessarabov,
Registration Date
31-01-2019
Organization
Kiev state university of technology and design
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The object of the study is organophosphorus toxic compounds (OTC) used as pesticides and active pharmaceutical ingredients (APIs). The purpose of the research is to create the scientific basis for the simulation of nanostructural ecological systems of decontamination by investigating the reactivity of target organophosphorus esters in the reactions of nucleophilic substitution with peroxide anion and its activated forms, as well as study of endo- and exotoxicity, bioaccumulation effects of OTC and products of their decomposition. Methods of investigation - to study the kinetic patterns of decontamination of OTC and the mechanism of inhibition of butyrylcholinesterase of human serum used by UV-Vis spectrophotometry; to prove the chemical structure and composition of the mixtures - FTIR-spectroscopy and HPLC. The scientific basis for the modeling of nanostructural ecological systems of decontamination by studying the reactivity of target organophosphorus ethers in the reactions of nucleophilic substitution with peroxide anion and its activated forms, as well as the study of endo- and exotoxicity, the effects of bio-accumulation of organophosphorus toxic substances and their decomposition products have been developed. The practical significance of the work is to establish an optimal decontamination system of organophosphorus organic substrates, ecotoxicants, based on an alkaline aqueous solution of cetylpyridinium chloride as a micelle forming agent, a solid hydrogen peroxide source as a nucleophile and a boric acid, an activator of hydrogen peroxide.
Product Description
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Вахітова Любов Миколаївна
Дерипапа В'ячеслав Сергійович
Здерко Назар Петрович
Кузьміна Галина Іванівна
Шелігацька Оксана Валеріївна
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2020-04-02
