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Information × Registration Number 0219U001053, 0117U000096 , R & D reports Title Synthesis of heterocyclic nitrogen and organo-phosphorus compounds and research of their biological activity. popup.stage_title Head Vovk A., Registration Date 09-01-2019 Organization V.P. Kukhar Institute of bioorganic chemistry and petrochemistry popup.description2 A series of new derivatives of 1,3-oxazole was synthesized, their antiviral activity against human papillomavirus virus in vitro with IC50 in micromolar concentrations was investigated. A convenient approach to the synthesis of substituted derivatives of pyrido [2,3-d] pyrimidin-7-one containing a nitrogen-containing substituent at the 4-position of the heterocyclic system was developed. Stereo-selective methods for the synthesis of - and -derivatives of tetradecapentaenoic acid, which were previously isolated from natural raw materials and are inhibitors of cell proliferation and apoptosis activators, have been developed. New approaches to constructing cholinesterase inhibitors have been developed, new O-substituted N-benzyl structural analogues of vitamin B1 have been synthesized and studied, which are capable of effectively and selectively blocking the activity of acetylcholinesterase and butyrylcholinesterase, which are targets for drugs in Alzheimer's disease. The directions of the construction of potentially bioactive nitro-derivative aurons as new antioxidants and xanthine oxidase inhibitors are substantiated. An analysis of the biological activity of a number of nitrogen heterocycles on plant model systems was carried out and this activity was comparable with natural phytohormones by cytokinins. Product Description popup.authors А.І. Вовк В.С. Броварець В.С. Кравець О.І. Колодяжний О.Б. Смолій popup.nrat_date 2020-04-02 Close