Registration Number
0219U003084,
0118U003210
, R & D reports
Title
To develop a complex treatment program for patients with secondary edematous breast cancer with researh of the mechanisms of pathogenesis of inflammatory and edematous components of aggressiveness of tumor process
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Head
Krasnoselskyi M.V., Доктор медичних наук
Registration Date
18-01-2019
Organization
State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine"
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Object of study: secondary-edematous Breast Cancer (SEBC) with different expression profiles of diagnostic and prognostic markers of tumor, inflammation and edema in 25 patients. The aim of study: to increase the efficiency of complex treatment of patients with secondary-edematous breast cancer by personalizing it on the basis of determining the role of inflammatory and edema components. Research methods and equipment: clinical and instrumental, biochemical, electron microscopic, morphological, immunohistochemical, statistical. Equipment - semi-automatic immunoassay analyzer Immunochem-2100, hematologic auto. Sysmex analyzer SF-3000. Theoretical and practical results: it has been determined that in the majority of patients with SEBC there is an increased level of expression of IL-6, VEGF and KI-67, and the connection between these factors is established, indicating the high aggressiveness of the tumor process, which is accompanied by inflammation. It was determined that among patients with SEBC the patients with a body mass index were over 30 prevailed. Novelty: a method for assessing the severity of perifocal edema in patients with SEBC in the dynamics of neoadjuvant treatment was developed. Implementation efficiency - abandoned duration of treatment of patients in the hospital on average for 5 bed-days, which saved 2575 UAH in the treatment of each patient in this group. Field of application: oncology and radiation medicine.
Product Description
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Єсіпова Н.М.
Білий О.М.
Гребіник Л.В.
Грушка Г.В.
Канцедал О.М.
Кондрашова О.I.
Красносельський М.В.
Лукашова О.П.
Мітряєва Н.А.
Мовчан О.В.
Насонова А.М.
Пономарьов І.М.
Потапова Т.І.
Радченко О.А.
Рубльова Т.В.
Слободянюк О.В.
Тесленко І.М.
Ткаченко Ю.В.
Шутов С.В.
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2020-04-02
