Registration Number
0219U003085,
0118U003211
, R & D reports
Title
To develop actions to improve results of complex treatment of patients with advanced endometrial cancer and recurrences of this disease
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Head
Mikhanovskiy О.A., Sukhina O.M.,
Registration Date
18-01-2019
Organization
State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine"
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Object of stady: a complex method of treatment patients with common endometrial cancer and relapse of the disease.Objective: to increase the effectiveness of complex treatment of patients with advanced endometrial cancer and disease recurrence by individualizing treatment based on studying the molecular biological features of the tumor and determining their prognostic value. Methods of research and equipment: clinical, radiological, immunological, morphological, statistical. Ultrasound diagnostic system ClearVue 550, Automatic hematology analyzer SF-3000 "SYSMEX". Theoretical and practical results: first of all was established dependence of the expression of the molecular and biological markers of patients with advance case of AC and relapse on the histological form of tumor. In patients with adenocarcinoma, the value of a positive and negative VEGF was observed in equal properties, on the background of the high-level Bcl-2 - 100%, a negative expression of mt p53 in 100% due, moderate proliferative activity Ki 67 - 50% and positive status of ER and PR (58,3 and 66,7%). Novelty: it has been proven that in patients with advanced endometrial cancer and disease recurrence, the expression level of molecular biological markers and ER receptors and PR depends on the histological formation of the tumor. The effective of implementation: оptimization of postoperative therapy with the high risk of relapse development and metastases endometrial cancer allowed 10% decrease in the number of cases of succession to the start of the first two years ago. Field of use: oncology.
Product Description
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Данілюк С.В.
Забобоніна Л.В.
Кругова І.М.
Міхановський О.А.
Моісеєнко Ю.А.
Насонова А.М.
Павліченко Ю.В.
Радченко О.А.
Сухін В.С.
Сухіна О.М.
Теплова М.А.
Федоренко Н.В.
Харченко Ю.В.
Щит Н.М.
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2020-04-02
