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Information × Registration Number 0219U003496, 0117U001159 , R & D reports Title Purposeful synthesis of rhenium compounds in low oxidation states and their biological activity nanoparticles popup.stage_title Head Shtemenko Olexander Vasylovich, Доктор хімічних наук Registration Date 19-02-2019 Organization State higher educational entity "Ukrainian State University of Chemical Technology" popup.description2 The object of investigation - the physico-chemical and biological properties of complex compounds of Re(III) and Re(I). The purpose of the work - to obtain a complex of experimental data about the interaction of complex compounds Re(III) and Re(I) with the components parts of biomolecules. Research methods - experimental studies with preparative chemistry and physico-chemical analysis using X-ray analysis, mass spectrometry, electronic, nuclear magnetic resonance (NMR) and infra-red (IR) spectroscopy. Experimental data were obtained: the effect of structure of the dirhenium(III) coordination compounds on the interaction with hemostasis proteins on the albumin example;binding of rhenium cluster compounds with purine and pyrimidine bases;the interaction of Re(III) compounds with the components of the nanoparticles matrix on the example of solid lipids;photophysical properties of Re(I) complex compounds with N-heterocyclic ligands.Was established: the length and branching of alkylhalocarboxylates dirhenium(III) affect the formation of system of protein-rhenium(III) compound; binding sites - N1/N6 for adenine, N7/O6 for guanine; the coordination of fatty acids up to the cluster fragment Re26 +; the investigated compounds exhibit luminescent properties with high quantum yields and Stokes shift. A new technical solution was developed, to which 1 application for the protection document of Ukraine for the invention was submitted. Fields of application: C 20.59 manufacture of other chemical products; C 21.20 production of pharmaceuticals and materials; P 85.42 higher education; Q 86.90 other activities in health protection. Product Description popup.authors Біленька Жанна Вячеславівна Баскевич Олександр Семенович Голіченко Олександр Анатолійович Овчаренко Аліна Олександрівна Пантелєєва Ольга Сергіївна Харлова Маргарита Ігоревна Штеменко Наталія Іванівна Штеменко Олександр Васильович popup.nrat_date 2020-04-02 Close