Registration Number
0219U003498,
0117U006416
, R & D reports
Title
Development of nanosystems for targeted drugs delivery.
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Head
Kytova Dina Yevgenivna, Кандидат хімічних наук
Registration Date
19-02-2019
Organization
State higher educational entity "Ukrainian State University of Chemical Technology"
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The object of research - complex compounds of Re (III) of different structural types, zirconium hydrophosphate layered nanoparticles and liposomes loaded with complex Re (III) compounds The purpose of the work is to create inorganic and organic phosphates nanosystems containing cluster dirhenium(III) compounds; to characterize their physicochemical, pharmacokinetic properties and efficacy. Methods of research - experimental research with the use of thermogravimetry, infrared, atomic absorption spectroscopy, X-ray powder diffraction, scanning electron microscopy, screening method for measuring cell activity. The interaction of cluster rhenium(III) compounds with zirconium hydrophosphate has been studied, methods of obtaining inorganic and organic phosphates nanosystems containing complex compounds of transitional elements with antitumor activity have been developed. The physicochemical properties of the obtained nanoparticles, which indicate the successful intercalation of cluster rhenium (III) compounds to nanosystems, were determined. It has been shown that the nature of release from nanosystems made targeted delivery of cluster rhenium(III) compounds possible. The normal and cancer cell killing efficacy of obtained nanosystems has been explored Branch of use: C 20.59 - manufacture of other chemical products n.v.i.u; C 21.20 - manufacture of pharmaceuticals and materials; P 85.42 – High education; Q 86.90 - Other health activities.
Product Description
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Ізюмський Максим Сергійович
Величко Олена Валеріївна
Китова Діна Євгеніївна
Пілецька Ксенія Олександрівна
Полохіна Катерина Сергіївна
Сліпкань Анастасія Валеріївна
Харлова Маргарита Ігорівна
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2020-04-02
