Registration Number
0219U004384,
0115U007178
, R & D reports
Title
To study the features of functional and structural changes in gastric mucosa in patients with precancerous lesions and to develop criteria for the formation of risk groups and treatment algorithm measures.
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Head
Mosiychuk Lidiya Nikolaevna,
Registration Date
24-06-2019
Organization
Ukrain Research Institute of Gastroenterology Ministry of Healthcare of the Ukraine
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The object of study is functional and structural disorders in the gastric mucosa in patients with chronic atrophic gastritis. The goal is to substantiate measures for the formation of risk groups with precancerous changes in the gastric mucosa on the basis of a comprehensive study of the influence of damaging factors and the development of a therapeutic algorithm. Research methods - clinical, instrumental, functional, histological, morphometric, immunohistochemical, biochemical, statistical. As a result of the study, factors that initiate perestroika changes in the gastric mucosa of precancerous directivity were identified: acute and chronic stress, anxiety and depression, eating excessive amounts of fried, smoked and pickled foods, patient's age, blood group II, oncological inheritance, the presence of duodenogastric reflux. The negative effect of increased concentrations of nitrates, nitrites and total nitric oxide in the blood and gastric contents on the macro- and microstructure of the gastric mucosa has been proven. Diagnostic criteria for the risk of dysplasia in the examined patients were determined with the calculation of their prognostic probability. The developed algorithm of management of patients with chronic atrophic gastritis.
Product Description
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Галінський Олексій Олексійович
Демешкіна Лариса Вікторівна
Зигало Ельвіра Вікторовна
Карачинова Вікторія Анатоліївна
Кушніренко Інесса Василівна
Мосійчук Лідія Миколаївна
Ошмянська Наталія Юріївна
Петішко Оксана Павловна
Руденко Анатолій Миколайович
Сімонова Олена Віталіївна
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2020-04-02
