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Registration Number

0219U004530, 0118U007314 , R & D reports

Title

Development of new methods for predicting the risk of developing and early diagnosis of endometrial cancer using epigenetic markers.

Head

Marichereda Valerya,

Registration Date

03-09-2019

Organization

Odesa National Medical University

Description

As a result of the research, it was found that the content of methylated GSHR DNA in tissue samples showed a high degree of hypermethylation of this gene in endometrial cancer tissue samples. The sumary level of the methylated DNA of the SFRP5 gene was significantly higher than in tissue samples with endometrial hyperproliferative processes. A reliable hypermethylation of the SFRP2 gene in endometrial cancer samples has also been proven. The content of methylated C-sites of the TNFa gene promoter in tissue samples in endometrial cancer was significantly lower than in samples of normal tissue. Thus, in conditionally normal tissue, the level of methylated DNA was higher than in patients with endometrial cancer, which is associated with the hypomethylation of the TNFa gene in endometrial cancer. Methylation of LEP and INFg gene promoters in endometrial cancer tissue samples, in comparison with conditionally normal endometrial tissue samples, was not significantly different.

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Бубнов Володимир Вячеслваович
Букреева Наталья Іванівна
Марічереда Валерія Геннадіївна
Рожковська Наталія Миколаївна