Registration Number
0219U005011,
0116U006001
, R & D reports
Title
Scientific substantiation of the use of analgesic and adjuvant drugs of antioxidant action under conditions of pain syndrome of traumatic genesis
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Head
Gubskiy Yuri Ivanovich,
Registration Date
11-04-2019
Organization
State Institution "Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine"
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The influence of adjuvant pharmaceutical drugs Gidazepam and Amitriptyline and their combined application with non-narcotic analgesic Ketorolak as to the state of lipid peroxidation processes in blood serum, erythrocyte membranes, liver homogenate and structural and dynamic indices of cellular membranes in conditions of experimental pain syndrome of traumatic genesis was studied. It was shown that the development of pain syndrome in rats causes activation of lipid peroxidation processes in serum, erythrocyte membranes and in the homogenates of the spinal cord took place. The drastic changes in the structure of the erythrocyte membrane, which lead to the increase in the membranes surface charge, as well as increase in the density of surface proteins and deep hydrophobic sections. It was also found that neurotropic drug Gidazepam possesses antioxidant and membrane stabilizing properties both in conditions of separate prophylactic and therapeutic administration, and in combined application with analgetic Ketorolak. The experimental data allow to assume that Gidazepam has the pharmaceutical properties of effective adjuvant in the case of anesthetics under traumatic lesions as such that significantly reduces the adverse biochemical and pathophysiologic effects of the pain pathology. Thus, Gidazepam and Amitriptyline are characterized by an analgesic effect against a pain syndrome of traumatic chemical genesis. Moreover, the results obtained suggest that the combined usage of Ketorolac and Hidazepam and Ketorolac and Amitriptyline is not leading to the leveling of the analgesic activity of Ketorolac. This knowledge is essential for creating effective pharmacological schemes of analgesics and adjuvant drugs usage in conditions of pain syndrome of traumatic genesis.
Product Description
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Бабенко Л.П.
Бершова Т.А.
Величко О. М.
Киричок Л. М.
Марченко О. М.
Мохорт М. А.
Серединська Н. М.
Суворова О. С.
Хоменко В.С.
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2020-04-02
