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Registration Number

0219U005475, 0114U007015 , R & D reports

Title

The detection of molecular and genetic markers to select and assess the efficacy of personalized pharmacotherapy in patients with Primary Arterial Hypertension and comorbidities.

Head

Shtanko Vasyl Andriyovich., Кандидат медичних наук

Registration Date

26-11-2019

Organization

Odesa National Medical University

Description

Factors affecting the insufficient effectiveness of treatment of patients with arterial hypertension (AH) and comorbid conditions have been identified. Associative relationships of individual polymorphic markers of nitric oxide synthase gene, angiotensinogen; angiotensinogen II type 1 and type 2 receptor genes and aldosterone synthase gene with features of clinical course of AH and target organ damage in patients of different age groups have been identified. Changes in the vegetative state, namely the prevalence of sympathicotonic influences, have been found to be associated with individual genotypes. It was determined that in elderly patients with concomitant coronary heart disease there are stage-dependent changes in the parameters of laser correlation spectrometry, which reflect the differences between the effects of combination therapy and its side effects. Methods of individualized approach to drug selection and dosing have been developed.

Product Description

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Курчик Тетяна Миколаївна
Тихонова Сусана Адольфівна
Тофан Наталія Вікторівна
Хижняк Олена Володимирівна
Холопов Леонід Семенович
Штанько Василь Андрійович