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Information × Registration Number 0219U100554, 0116U004902 , R & D reports Title To study the mechanisms of tissue responses, links intercellular interactions, especially the regenerative processes in the local thermal damage in violation of carbohydrate metabolism. popup.stage_title Head Natrus Larysa V., Доктор медичних наук Registration Date 19-02-2019 Organization Bogomolets National Medical University, Ministry of Health of Ukraine popup.description2 It was found:There were carried out the pathomorphological, histochemical, ultrastructural researches of the skin burn wound healing dynamic (3, 7, 14, 21 days) of the white mature male rats (Wistar line) with the weight of 180-210g without somatic pathology (control group, n=28) and with stable uncorrected hyperglycemia modeled by streptozotocin (n=28). In the regenerate of tissue the content of phosphorylated Ser 311 subunit p65 of the kappa N factor-B (NF?B), the I?B-? , the VEGF vascular endothelial cell growth factor (VEGF), the receptor of VEGF (Flt1) was investigate by Western blot analysis. In these terms, myelogram was perform according to the standard method and the calculation of the elements of the peripheral blood. The obtained data provided the basis for creating the concept of a multilevel regulatory chain of the normal physiological conditions neoanogeogenesis. Under normal physiological conditions: the nuclear factor of pNF-?B causes the production of myeloid precursors growth factors, the humoral signal enters the bone marrow and regulates the proliferation of neutrophilic granulocytes and their release from BM to peripheral blood (PB). Neutrophils express endothelial growth 9.3аключні відомості Керівник організації factors, and regulate expression of the receptors to these ligands in the connective tissue regenerate, which leads to performing angiogenesis, which is regulated. So, during hyperglycemia, the change in the sequence of wound healing reactions, the change in intercellular cooperation and the decrease in the effectiveness of paracrine effects between cells in the form of regulatory signals for stimulation of angiogenesis is determined, which leads to pathological changes in blood vessels and prevents normal physiological course of healing. Product Description popup.authors popup.nrat_date 2020-04-02 Close