Registration Number
0219U100992,
0116U002684
, R & D reports
Title
Develop methods of surgical (iridocyclectomia), laser (transpupillary thermotherapy) and combined (radiocryosurgery) treatment of malignant tumors of the uvea and conjunctiva and determine the mechanisms for implementing the therapeutic effect of these methods
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Head
Vit Valerii V., Доктор медичних наук
Registration Date
23-04-2019
Organization
State Institution "The Filatov Institute of Eye Disease and Tissue Therapy of NAMS of Ukraine"
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Object of research: experimental animals (rabbits); patients with malignant epibulbar neoplasms (melanoma, squamous cell carcinoma) and uveal melanoma.The purpose of the study: to study the mechanisms of the therapeutic effect of the new surgical (iridocyclectomy), laser (transpupillar thermotherapy) and combined (radiocryosurgery) treatment of malignant neoplasms of the uvea and eye conjunctiva.Methods of research: ophthalmologic, hystomorphological, cytomorphological, sonographic.The results of the study: it was found that the inflammatory reaction of the soft tissues of the orbit was more pronounced around the polytetrafluoroethylene implant and was stored for up to 30 days, whereas around the PCM it was less pronounced and lasted for up to 10 days. The clinical and structural features of the tissues in the postoperative course, the timing of the formation of the fibrovascular capsule and the maturation of the connective tissue around the implant were studied. It was established that according to the data of the treatment at the Filatov Institute of Eye Diseases and Tissue Therapy from 1999 to 2018 among patients with epibulbar neoplasms predominated patients with melanoma (60.9%), most of whom were residents of the city (60.9%). Among patients with jatrogenic tumors, the most frequently observed tumors after surgical removal (60% - melanoma, 83.3% - cancer). Most malignant epibulbar neoplasms were registered up to one year from the moment of the disease. In the US study, it was found that with partial resorption of melanoma, the thickness of the sclera under the tumor was 1.3, and at the cancer - 1.6 times thinner than with full resorption. At recurrences of epibulgar melanoma and cancer the average echogenicity of a tumor is more common. The comparison of the data of the clinical and impression-cytological (IC) data with the pathomorphological data in 189 patients with melanocytic (91 patients) and epithelial (98 patients) tumors of the conjunctiva was perfor
Product Description
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Elagina Viktoria A.
Bogdanova Oleksandra V.
Borisova Maryna I.
Buyko Oleksandr S.
Vit Valerii V.
Velychko Liudmyla M.
Gavronska Natalia M.
Zadorozhnyi Oleg S.
Kovalchuk Oleksandr G.
Maletskiy Anatoliy P.
Maltsev Eduard V.
Molchanuk Natalia I.
Piterova Olga V.
Poliakova Svitlana І.
Safronenkova Irina O.
Homiakova Olena V.
Tsukanova Inna V.
Chernezhenko Karina A.
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2020-04-02
