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Registration Number

0219U101945, 0119U003022 , R & D reports

Title

Analysis of the influence of different forms of calix [4] arenes on cell proliferation of different origin.

Head

Garmanhuk Ludmila V., Доктор біологічних наук

Registration Date

03-12-2019

Organization

Taras Shevchenko National University of Kyiv

Description

 Object of study: Proliferation rates of colon and gastric cancer tumor cells Purpose: To determine the effect of different forms of calix [4] arenas on the proliferation of tumor cells of different origin Research methods: methods of cell culture, determination of growth characteristics of tumor cells, morphological analysis. The study found that the tested compounds of calix [4] arena C-145, when screened for colon and gastric cancer cells, showed an anti-proliferative effect and revealed a population redistribution in Colo 205 cells, which indicated an increase in the clastin fraction fraction; AGS gastric cancer cells did not change their morphological parameters; the nuclear cytoplasmic ratio remained flat in control without the addition of calix [4] arenas.

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