Registration Number
0219U102047,
0115U002951
, R & D reports
Title
Identification of genetic and epigenetic changes in cell-free DNA in blood of renal cancer and breast cancer patients as diagnotic and prognostic markers for early non-invasive diagnostics.
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Head
Skrypkina Inessa Ya., Кандидат біологічних наук
Registration Date
16-12-2019
Organization
Institute of Molecular Biology and Genetics of NAS of Ukraine
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As a result of Phase 5 of the project, the expression levels of micro RNA in samples of patients with kidney cancer were tested. For this purpose, using bioinformatics online resources, in the 3'-untranslated regions of suppressor genes involved in the processes of carcinogenesis, the target sites for miRNAs were identified and the expression of the most promising ones was verified. Studies have shown that in kidney tumors, miR-30c-5p and miR-138-1 mRNA levels are reduced 6-7 times compared to normal tissues and 6-9 times in the blood plasma of patients, as opposed to healthy donors.
Product Description
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Anopriyenko Olga V.
Areshkov Pavlo O.
Onyshchenko Kateryna V.
Shablii Volodymyr A.
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2020-04-02
