Registration Number
0219U102195,
0119U101912
, R & D reports
Title
Hydrogen-deuterium exchange mass spectrometry as a qualitatively new approach for the investigation of the spatial structure of the eEF1B translation complex in the solution
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Head
Negrutskyii Borys S., Доктор біологічних наук
Registration Date
20-12-2019
Organization
Institute of Molecular Biology and Genetics of NAS of Ukraine
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The spatial structure and state of aggregation of eEF1Ba subunit of the eEF1B translation complex have been studied. This protein has been shown to belong to a family of partially unstructured elongated proteins. The state of aggregation of the eEF1Bb * eEF1Bg complex and the spatial shape of this complex, as well as the areas of interaction of the eEF1Ba subunit with the eEF1Bg subunit in such complex, were studied. The structural regions of the N-terminal fragment of the eEF1Ba molecule that are involved in the formation of the eEF1Bag complex were first identified.
Product Description
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Bondarchuk Tetyana V.
Vlasenko Dmytro O.
Lysetskyi Igor L.
Lozhko Dmytro M.
Luk`yanenko Ganna I.
Negrutskyii Borys S.
Novosylna Oleksandra V.
Porublova Larysa V.
Shalak Viacheslav F.
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2020-04-02
