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Information × Registration Number 0220U000251, 0117U003028 , R & D reports Title To study biochemical, genetic mechanisms of reperfusion myocardial injury and evaluate cardiioprotective effect of antiplatelite therapy in acute myocardial infarction. popup.stage_title Head M.Kopytsya, Registration Date 24-01-2020 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description2 341 patients with myocardial infarction with ST segment elevation and post-infarction cardiosclerosis were observed. A general examination of patients, ultrasound, electrocardiography, enzyme-linked immunosorbent assays, real-time polymerase chain reaction was carried out. It has been proven that ticagrelor and clopidogrel have not shown benefits in restoring myocardial blood flow after STEMI. With prolonged administration (more than 6 months), ticagrelor comparing with clopidogrel significantly reduced the frequency of adverse cardiovascular events (from 31.6% to 14.2%, p = 0.004). The high sST2 level determined in the first hours of STEMI (> 34.2 ng/ml) with a sensitivity of 92.3% and a specificity of 62.5% predicted an adverse course of revascularization of a infarct-related coronary artery (blood flow level on a TIMI scale of 0-2) (p = 0.0001). The MIF level of more than 3663 ng/ml in the first hours of STEMI may be a predictor of myocardial perfusion disturbance (MBG 0-1, pST <70%) after successful PCI (AUC = 0.737; 95% CI 0.584-0.857; p = 0.0023). The 786CC genotype of the eNOS gene is able to independently predict late remodeling of the left ventricle after myocardial revascularization. Product Description popup.authors Ващенко В.Г. Вишневська І.Р. Внукова І.Л. Воронова Н.І. Гільова Я.В. Гончар О.В. Кобець А.В. Костюк О.І. Кутя І.М. Пєтєньова Л.Л. Петюніна О.В. Родіонова Ю.В. Стороженко Т.Є. Титаренко Н.В. Юхновський Ю.О. popup.nrat_date 2020-04-02 Close