Registration Number
0220U000677,
0117U006446
, R & D reports
Title
Efficacy, cardio- and gastrointestinal safety of immunosuppressants and calcium antagonists of the dihydropyridine series when combined in a model of rheumatoid arthritis combined with arterial hypertension
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Head
Seredinskaya Nataliya Nikolaevna, Доктор медичних наук
Registration Date
02-11-2020
Organization
State Institution "Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine"
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Possibilities and expediency of the combined use of synthetic-derived immunosuppressants (on the example of leflunomide) and biological origin (on the example of the genetically modified drug enbrel) with non-steroidal anti-inflammatory drugs, different in selectivity for cyclooxygenagnosis, have been investigated with adjuvant arthritis. The features of cardiotropic action of immunosuppressants and amlodipin for their combined long-term use are determined, the necessity of monitoring indicators of cardiovascular system activity against the background of a comorbid state is proved, which allows to optimize the ways of choice of the means of the three specified pharmacotherapeutic groups and to improve the treatment of mediterranean patients. that accompanies or appears on rheumatoid arthritis.
Product Description
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Акімова Н. В.
Бершова Т. А.
Киричок Л. М.
Марченко О. М.
Матвієнко А. В.
Мохорт Н. А.
Серединська Н. М.
Суворова О. С.
Хоменко В. С.
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2021-03-17
