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Information × Registration Number 0220U000688, 0117U006445 , R & D reports Title Optimization of structures of potention bioactive compounds with analgesic and antiinflammatory activity in of series of condensed azole and azine-containing heterocycles popup.stage_title Head Demchenko Anatoliy Michaylovich, Seredinska Natalia Mykolayvna, Registration Date 02-11-2020 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 Modification of the compounds of the leaders of the triazolo-thiadiazine and imidazo-thiazine derivatives was carried out. According to QSAR, the predicted effective dose ranges are determined (from 11.48 mg / kg to 26.64 mg / kg and from 2.17 mg / kg to 2.84 mg / kg, respectively). Molecular docking of the investigated compounds in COX-2 was performed, negative binding energies were calculated, amino acid environment of the ligands was investigated at COX-2 sites. The pain and anti-inflammatory effects of the synthesized compounds were experimentally determined. Product Description popup.authors Баглай Олександр Юрійович Бершова Тетяна Анатоліївеа Бобкова Людмила Станіславівна БухтіароваТетяна Анатоліївна Голубов Михайло Іванович Демченко Сергій Анатолійович Козир Віталій Анатолійович Ктртчок Лариса Михайлівна Лук янчук Віктор Дмитрович Марченко Олена Миколаївеа Середенко Ольга Володимирівна Суворова Олександра Сергіївна Хайрулін Андрій Рашидович Хоменко Василь Станіславович Ядловський Олег Євгенович popup.nrat_date 2021-03-17 Close