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Registration Number

0220U001265, 0117U007012 , R & D reports

Title

The study of dysbiotic aspects of the pathogenesis and the antidysbiotic prevention of noninfections diseases, including stomatological ones.

Head

Levitsky Anatoly Pavlovich,

Registration Date

18-02-2020

Organization

Odessa Scientific Research Institute of Stomatology

Description

Object of study - non-infectious diseases, dysbiosis, non-specific resistance, antidysbiotic prophylaxis. The purpose of the work is to develop antidysbiotic methods for the prevention of non-infectious diseases of different genesis (periodontitis, gastritis, gastroduodenitis, peroxide intoxication, iatrogenic maxillary sinusitis, hepatobiliary pathology). Research methods are experimental, clinical, biochemical, immunological, electron microscopic and statistical. Equipment - UV mini-1240 Shimadzu spectrophotometer, EV-74 ionomer, Scales electronic BL-220H, PC-6 centrifuge. Scientific novelty: 1) The universality of the development of dysbiosis in any non-infectious diseases realized due to the influence of lipopolysaccharide on the activity of tissue lysozyme has been established. The studies carried out supplemented the previously obtained information on the leading role of decreased antimicrobial function of the liver in the pathogenesis of generalized and local dysbiosis. The concept of a new nosological form "dysbiotic syndrome" is substantiated. 2) The pathogenetic role of multifunctional antidysbiosis agents, including the first developed ones, in the prevention of non- infectious diseases, including dental ones, is shown. Clinical studies have established the effectiveness of dental prophylaxis with the help of the gel "Lekvin" in patients with gastroduodenitis and hepatobiliary pathology, as well as the drug "Lysozyme-forte" in patients with gastritis and gastroduodenitis. 3) Clinical and statistical analysis of indicators of general immunity of patients with various forms of iatrogenic maxillary sinusitis was performed. Practical value: The expediency of using the method of determination of urease activity for the evaluation of microbial contamination of organs and tissues, the method of studying the activity of lysozyme for determining the degree of reduction of the level of nonspecific immune system, the method of studying the activity of elastase for the assessment of the severity of the inflammatory process. Previously developed multifunctional anti-dysbiotic agents Lekvin (tablets, powder) patent No. 108536, TU 10.8-37420386-003: 2016 dated 26.03.2016, Conclusion of the State Sanitary and Epidemiological Expertise No. 05.03.02-06 / 8400 dated 21.03.2016) "Lysozyme-forte" (tablets, powder) (by TUU 10.8-37420386-004: 2016, Conclusion of the State Sanitary and Epidemiological Expertise No. 602-123-20-2 / 5734 of 22.12.2016) was investigated in an experiment on 2 models (toxic hepatitis, peroxide periodontitis) and in a clinic in 547 patients with gastroenterological pathology (gastritis, gastritis, gastritis, hepatitis, colitis), determined their stomatotropic effect. Experimental and industrial production of the following means was carried out: Lekvin, Lysozyme-forte, Lekvin-gel, "Dubovyi" gel. "Phytogel Lekvin" (RC U 20.4-13903778-032 / 12: 2016 dated 01.03.2016, Conclusion of the State Sanitary and Epidemiological Expertise No. 05.03.02-07 / 5740 dated 25.02.16 according to TUU 20.4-13903778-032: 2012 "Phytogels", Conclusion of the State Sanitary and Epidemiological ExpertiseNo. 05.03.02-04 / 5746 from 02/25/16 in 20.4-13903778-032 / 12: 2016 from 01.03.2016 to 20.4-13903778-032: 2012 "Phytogels"). Formulation of Phytogel "Dubovyi" (RCU 20.4-13903778-032 / 13: 2017 Phytogel "Dubovyi" from 20.04.2017 to TU 20.4-13903778-032:2012 "Phytogels "). Materials research works are published in 68 articles, 4 methods recommendations, 31 theses, 5 innovations. 6 utility model patents received. 4 innovation projects submitted. ANTI-DYSBIOSIS MEANS, DYSBIOSIS, LYSOZYME, NON-INFECTIOUS DISEASES, PATHOGENES

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Біда Андрій Валерійович
Богату Світлана Ігорівна
Борис Галина Зіновіївна
Бочаров Андрій Володимирович
Варжапетян Сурен Діасович
Дізік Світлана Валеріївна
Декіна Світлана Сергіївна
Кононова Оксана Валеріївна
Макаренко Ольга Анатоліївна
Мудрик Любов Михайлівна
Остафійчук Маріанна Олександрівна
Почтар Вікторія Миколаївна
Романовська Ірина Ігорівна
Сєнніков Олег Миколайович
Селіванська Ірина Олександрівна
Скиба Василь Яковлевич
Томіліна Тетяна Вікторівна
Фурдичко Анастасія Іванівна
Хромагіна Лариса Миколаївна
Шварцнау Олена Генадієвна