Registration Number
0220U100060,
0115U003906
, R & D reports
Title
Investigation of biologically active substances and the optimization of pharmaceutical and health care through the discovery of new properties, patterns, correlations.
popup.stage_title
Head
Deviniak Oleh T.,
Registration Date
08-01-2020
Organization
State University "Uzhhorod National University"
popup.description2
QSAR models of the antitrypanosomal activity of 4-thiazolidinones based on Random Forest, MARS and Gaussian processes regression are developed. Good prognostic validity of these models secures their use for in silico screening purposes. The best ratio of raw plant material and oil (1:5) for the extraction of carotenoids is figured out. The toxic effects of apricot leafs extract have been evaluated, proving its non-toxicity (LD50 > 5000mg/kg). The major compounds in the ethanol extract from Lamium album were found to be methyl ester of 3-oxo-2-penthylcyclopenthaneacetic acid and ethyl ester of butyric acid. The series of clinically significant correlations that line Parkinson’s disease course together with functional reserves of an organism have been identified and discussed.
Product Description
popup.authors
Bysaga Elisaveta I.
Deviniak Oleh T.
Krch Khristina L.
Malyi Volodymyr V.
popup.nrat_date
2020-04-02
