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Information × Registration Number 0220U100179, 0117U003074 , R & D reports Title To determine a significance of gene polymorphism of the P-450 cytochrome system in mechanisms of formation of pharmacologically resistant forms of epilepsy in children, to optimize approaches to diagnosis and to treatment popup.stage_title Head Tantsura Liudmyla М., Доктор медичних наук Registration Date 13-01-2020 Organization State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine" popup.description2 Keywords: children, epilepsy, pharmacoresistance, pharmacogenomics, cytochrome P450. Study subject: clinic-anamnestic, clinic-neurologic, neurophysiologic, neuroimaging and pharmacogenetic data of children with pharmacologically resistant epilepsy. Data volume: 116 children of age between 11 months and 18 years (63 boys, 53 girls). Research goal: to work out and implement personalized approaches to pharmacologic therapy correction in children with pharmacologically resistant epilepsies, which take into consideration polymorphism of cytochrome P450 genes; to evaluate their efficacy and safety. Methods: clinico-anamnestic, clinico-neurologic, clinico-neuropsychological, neurophysiologic, neuroimaging genetical (alell-specific PCR), statistical. There were discovered that some single nucleotide polymorphisms present in 64,66 % of the studied group; defined that polymorphisms frequency of CYP3A4*1B and CYP2C19*2 is reliably higher than in general Ukrainian and other European populations; frequency of CYP2С19 polymorphisms is definitely higher than by Russian, Turkish and Indian researchers’ data for children with epilepsy. Peculiarities of epilepsy course in children with cytochrome P450 genes’ polymorphisms were defined, approaches for antiepileptic drag correction were worked out and had been shown that their implementation allow to achieve seizure control in 26,19 % children and 50 % seizure decrease in 23,80 % patients. Product Description popup.authors Ena Raisa A. Grokhovsky Vladimir V. Lukiantseva Olga Yu. Pylypets Olena Yu. Pryvalova Nataliya M. Sazonov Serhii O. Serhii Salo Serhii V. Semenova Ruzana M. Trembovetska Olena V. Tretiakov Dmytro Shatillo Andriy V. popup.nrat_date 2020-04-02 Close