Registration Number
0220U100284,
0119U102168
, R & D reports
Title
Determining the interaction of pharmaceutical nanocarriers with model phospholipid membranes.
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Head
Lisetski Longin М., Доктор фізико-математичних наук
Registration Date
14-01-2020
Organization
Institute for scintillation materials NAS Ukraine
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Liposomal nanocarriers loaded with with pharmaceuticals azithromycin or fenspiride have been developed. A possibility of modulation of membranotropic activity of the pharmaceuticals depending on lipid composition was shown. The key role of the salt composition of media for such liposomal characteristics as diameter, polydispersity and ξ-potential was determined. Interaction kinetics of the liposomal carriers loaded with azithromycin or fenspiride with model lipid membranes was studied. It was established that interaction of pharmaceuticals with lipid membranes occurs on the background of mutual diffusion of membrane and liposomal lipids.
Product Description
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Budyanska Lily V
Vashchenko Olga V.
Kasyan Natalia О.
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2020-04-02
