Registration Number
0220U100473,
0118U003208
, R & D reports
Title
Pathogenesis of immunoneuroendocrine disorders associated with metabolic disruptions in patients with endometrial and breast cancer in surgery and radiation therapy
popup.stage_title
Head
Prokhach Nataliia E., Кандидат медичних наук
Sorochan Pavel P., Кандидат медичних наук
Registration Date
20-01-2020
Organization
State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine"
popup.description2
Object of investigation: immunological, hematological and psychosomatic disorders at combined therapy in endometrial and breast cancer patients. Purpose of the work: to develop a technology for predicting immune disorders and quality of life level after combined treatment, taking into account separate metabolic disorders in patients with endometrial and breast cancer. Methods of investigation and equipment: immunological, hematological, biochemical methods; light microscopes, flow cytofluorimeter, spectrophotometer, hematological and immune enzyme analyzers. Theoretical and practical results: it was found that patients with severe metabolic disorders have high levels of immunosuppressive cells CD4+PD1+, CD8+PD1+, CD14+PDL1+, as well as NKT cells and lower of CD19+, CD3+CD8+ and CD3+HLA-Dr+-lymphocytes than in patients with minor metabolic disorders. A positive correlation between the absolute number of lymphocytes and insulin level and negative correlations with the level of C-reactive protein and IL-6 were established. In patients with grade III obesity, a greater severity of psychosomatic disorders was noted at the stages of antitumor treatment. Novelty: for the first time, a complex of immune changes was determined, which consists in a pronounced deficiency of CD19+-, CD3+CD8+- and CD3+HLA-Dr+-cells and an increase in the relative number of cells with immunosuppressive activity – CD4+PD1+-, CD8+PD1+, CD14+PDL1+ and NKT-cells, which occur during radiation therapy of patients with endometrial and breast cancer with pronounced metabolic disorders. The role of insulin and C-reactive protein imbalance in the development of lymphopenia after radiation therapy of patients with metabolic disorders has been established. Efficiency of introduction: the prognosis of immune disorders allows to reduce the term of hospitalization of the patient by 5 days (saving 2860 UAH per patient). Sphere of application: oncology, radiology.
Product Description
popup.authors
Yevdokymenko Viacheslav I.
Ivanenko Maryna O.
Hromakova Inna S.
Hromakova Iryna A.
Kosheleva Iryna V.
Kuzmenko Olena V.
Nikitin Mykyta I.
Nemaltsova Kateryna V.
Polozova Mariia V.
Ponomarov Ihor M.
Prokhach Nataliia E.
Radchenko Oleksandr A.
Revenkova Svitlana I.
Sorochan Pavlo P.
Tepla Viktoriia O.
Teplova Maryna A.
Tolkachov Yurii A.
Tretiak Maryna Yu.
Shevtsov Vasyl H.
popup.nrat_date
2020-04-02
