Registration Number
0220U100545,
0119U002252
, R & D reports
Title
Sulfurfunctionalized carboxy- and heterocyclic systems with anti-platelet and antioxidant activities as new promising substances for treatment of arterial thrombosis
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Head
Registration Date
21-01-2020
Organization
Lviv Polytechnic National University
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The results of computer prediction of the probable manifestation of antiplatelet and antioxidant activities for sulfur-containing derivatives with carbo- and heterocyclic moieties using the online PASS Online program of the Way2Drug platform and molecular modeling of interaction with target receptors are presented. Optimal conditions for S-alkylation of the sodium salts of p-amino(p-acetylamino)-benzentiosulfonic acids by halomethyl and halogen-containing derivatives of quinones and quinoxalines have been developed. New thiosulfonate derivatives of 1,4-dimethoxyanthracene-9,10-dione, 2- (methylene)-, 2,3-bis(methylene)quinoxalines, 2-(methylene)- and 3-(methylene)-1-methyl-1H-benzo[f]indole-4,9-dione and 1,4-naphthoquinone were synthesized. A convenient way of obtaining of new perspective mono- and bisdithiocarbamate 9,10-anthracendione derivatives under non-catalytic reaction conditions in aqueous medium was proposed, and the behavior of the synthesized compounds under H2SO4-AcOH (1: 3) and 70% HClO4 was investigated.
Product Description
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Bobalo Ihor Yu.
Voytsakhivska Olga S.
Zvarych Viktor I.
Karkhut Andriy I.
Lubenets Vira I.
Monka Natalia Ya.
Moskalenko Nataliya
Nakonechna Anna V.
Roman Yuriy V.
Stasevych Maryna V.
Shyian Galyna B.
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2020-04-02
