Registration Number
0220U100623,
0119U100340
, R & D reports
Title
Promising molecular tools based on natural and synthetic (carbo) heterocycles to solve problems of chemistry, medicine, industry.
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Head
Khylia Volodymyr P.,
Registration Date
22-01-2020
Organization
Taras Shevchenko National University of Kyiv
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Object of study - N-, O-, S-containing (carbo) heterosystems.
Purpose - Development of new synthetic methodologies for constructing carbocyclic and heterocyclic compounds as promising molecular tools, methods for the synthesis of analogues of structurally similar to natural compounds and / or known drugs, study of chemical transformations, structural features, spectral characteristics, physico-chemical properties practically useful substances and materials.
Research methods - methods of synthesis of model organic compounds, heterocyclic compounds; NMR, IR, UV, fluorescence spectroscopy; mass and chromatomy-spectrometry; methods of synthesis under high pressure and in an inert atmosphere; X-ray and elemental analysis, in silico, in vitro and in vivo screening.
Methods for the synthesis of flavonoid derivatives, β-keto-γ-sultams, oxazole, (carbo) heterocycles and spirocycles containing CF2 group have been developed for the needs of medical chemistry. Generally known data and authors' own research on modern methods of synthesis, modification and biological activity of (iso) coumarins, neoflavones, condensed chromones, asahromones. Developed: new building blocks based on deoxybenzoins, (iso) coumarins, (iso, neo) flavones, methods for synthesis of new heterocyclic systems based on them, enamino ketone 2'-carboxamidodeoxybenzoin, 1λ6-isothiazolidine-1,1,4-trioxin, macrocodine oxazole. For diazepinone derivatives, liver tissue respiration and liver bile secretion were investigated.
Product Description
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Vovkun Tetyana V.
Gorbulenko Nataliya V.
Hryhorenko Oleksandr O.
Dobrydnev Alexey V.
Moskvina Viktoria S.
Potikha Lyudmyla M.
Tarasyuk Taras M.
Khylia Volodymyr P.
Schokol Tetyana V.
Shtanova Lidiya Ya.
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2020-04-02
