Registration Number
0220U100755,
0117U004270
, R & D reports
Title
To investigate the effectiveness of innovative methods of the experimental spinal cord and peripheral nerve restoration using tissue neuroengineering and electro-surgery technology.
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Head
Tsymbaliuk Vitalij I., Доктор медичних наук
Registration Date
24-01-2020
Organization
The State institution "Romodanov neurosurgery institute, National academy of medical sciences of Ukraine"
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In this study, data on the effectiveness of immediate filling of the adult rat's sciatic nerve defect with a collagen tubular conduit with neural crest stem cells are retained. The results indicate that there is no significant difference between the tissue-engineered tool and conventional autoneuroplasty; tested tool has significant potential for improvement and is characterized by significantly faster regeneration. Transplanted neural crest stem cells were differentiated into schwann cells and provided myelination of newly formed nerve fibers. Tested welded joint of the ends of the transsected sciatic nerve in some electroneuromyographic and morphometric parameters outperforms traditional neuroraphy. Implantation of a chitosan-based tunneling matrix into the spinal cord injury zone significantly impairs the regeneration process, potentiate post-traumatic spasticity.
Product Description
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Velichko Olga M.
Veselova Olga I.
Gridina Nina Ya.
Draguntsova Natalia G.
Medvedev Volodymyr V.
Molotkovets Vitaliy Yu.
Nakhaba Oleksandr O.
Petriv Taras I.
Senchyk Yurii Yu.
Tatarchuk Mikhail M.
Tsymbaliuk Vitaliy I.
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2020-04-02
