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Information × Registration Number 0220U100821, 0119U002807 , R & D reports Title Synthesis and antiaggregative activity of fibrinogen receptor antagonists based on 2,6-diaminoquinazolines scaffold that containing residue of -substituted GABA. popup.stage_title Head Kornylov Oleksandr Yu., Registration Date 28-01-2020 Organization Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine popup.description2  The object of research – derivatives of 2,6-diaminoquinazoline containing at the second position of the quinazoline piperazin-1-yl, gomoperiperazin-1-yl and 2,5-diazabicyclo[2.2.1]hept-2-yl groups; and in the sixth position of the quinazoline – amides of 3-substituted GABAs. The aim of 1st stage of research - the molecular design of potential fibrinogen receptor antagonists based on 2-piperazinylquinazoline, 2-homopiperazinylquinazoline and 2,5-diazabicyclo[2.2.1]heptylquinazoline; synthesis of intermediate Boc-N-protected derivatives of 3-substituted GABAs to obtain subjects for exploration. The design of “nonclassical” potential antagonists of fibrinogen receptors based on 6-amino-2-piperazinylquinazoline, 6-amino-2-homopiperazinylquinazoline and 6-amino-2,5-diazabicyclo[2.2.1] heptylquinazoline derivatives was carried out. As the amino acid fragment for the amino group of the 6th position of the quinazoline were selected 3-substituted GABA containing phenyl, 4-chlorophenyl and 4-methoxyphenyl in the 3-position. The literature review was performed on the methods of synthesis of 3-substituted GABAs, the optimal methods, which allow to synthesize the planned objects were selected. According to the 6-step scheme, Boc-N-protected 3-phenyl derivatives of GABAs, which will later be used to obtaining new fibrinogen receptor antagonists were synthesized. Product Description popup.authors Kornylov Oleksandr Yu. popup.nrat_date 2020-04-02 Close