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Information × Registration Number 0220U100881, 0117U004537 , R & D reports Title To develop effective methods of standardization and indexation of prenatal ultrasound measurements in fetuses with congenital malformations in order to optimize management of pregnancy, delivery and surgical correction in neonates popup.stage_title Head Avramenko Tetyana V., Доктор медичних наукGordienko Iryna Yu., Доктор медичних наукSlepov Oleksii K., Доктор медичних наук Registration Date 29-01-2020 Organization State Institution "Institute of pediatrics, obstetrics and gynecology named after acad. O.M. Luk'yanova of National academy of medical sciences of Ukraine" popup.description2  Object of the study: fetuses and newborns with congenital diaphragmatic hernia, gastroschisis and high intestinal atresia, pregnancy and labor in women with the abovementioned malformations in the fetus. Research methods: clinical and statistical, ultrasound exam of the fetus, invasive procedures with cytogenetic analysis of chorionic/placenta bioptate, amniotic fluid, fetal blood by conventional methods. Equipment: ultrasonic diagnostic scanners ACCUVIX V20EX-EXP, ACCUVIX V10LV-EX. Comparative analysis of data on complex prenatal investigations, pregnancy and labor course, and postnatal outcomes in congenital diaphragmatic hernia, gastroschisis and high intestinal atresia was performed. High variability of clinical and anatomical features of these malformations was demonstrated, which results in variability of clinical outcomes, and requires a systematic standardized approach to prenatal examinations. Dynamic changes of prenatal clinical features during pregnancy were demonstrated, which complicates prediction of perinatal outcomes in the second trimester. Mathematically and clinically grounded, term-independent prognostic indices were proposed. The prognostic value of mathematical and clinical anatomical markers has been determined. A standardized algorithm for prenatal examination with a focus on common and specific prognostic markers was scientifically substantiated. Clinical and anatomical classifications of these malformations were developed, which allows to distinguish groups of patients with different prognosis - favorable, doubtful or unfavorable. According to the prognosis for the newborn, an individualized management of pregnancy and delivery, as well as specialized help to neonates is planned. The results of the implementation of prenatal dispensary system and management of patients in a single medical institution were demonstrated, namely the reduction of postoperative mortality in congenital diaphragmatic hernia and gastroschisis. Product Description popup.authors Boluh Victoriia M. Vashchenko Oksana О. Velychko Andriy V. Grebinichenko Ganna O. Hryshyna Tomara O. Dzham Oleg P. Kaniovska Valentyna A. Kryvushchenko Iryna V. Marchyk Oleksandr O. Mellina Irina M. Migyr Mikhailo Yu. Mosalska Maryna Yu. Nikitchyna Tetiana V. Nosko Alla O. Ponomarenko Oleksiy P. Rachenko Kateryna V. Soroka Vasyl' P. Tarapurova Olena M. Tsypkun Viacheslav A. popup.nrat_date 2020-04-02 Close