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Information × Registration Number 0220U100934, 0119U100320 , R & D reports Title Selectivity in the reactions of carbo-, heterocyclic and functionalization for medical chemistry and sustainable development. popup.stage_title Head Voitenko Zoia , Доктор хімічних наук Registration Date 29-01-2020 Organization Taras Shevchenko National University of Kyiv popup.description2 Object of study: heterocyclic compounds, incl. Nitrogen-containing (isoindoles, fused isoindoles, their heteroanalogs, quinazolones, their heteroanalogues, pyridine-containing amino acids, maleic and succinimides, etc.) and oxygen-containing (chromons and their derivatives, condensed oxy-genotomyogens. Purpose: development of modern selective and preparative synthetic approaches for obtaining new molecules of carbo- and heterocyclic nature, as well as their further controlled functionalization for medical chemistry and sustainable development. Research methods: study of spectral and computer methods of influence of various factors that determine the selectivity of the studied reactions of carbo-, heterocyclization and functionalization (catalyst, solvent, temperature, electronic nature of substituents, steric factors, etc.), study of fluorescence spectra. The influence of steric and electronic factors on the course of the cyclic coupling reaction with pyrrolidine-2,5-dione is established. The influence of reaction conditions on the selectivity of cyclization under the interaction of 3- and 4-nitrophthalonitrile, as well as pyridine-2,3-dinitrile with amines, carboxylic and amino acid hydrazides has been established. Preparative methods for the synthesis of new amino and hydrazide derivatives of aminoisoindole and its azoanalog as potential antimalarial agents and compounds with herbicidal activity have been developed. Principles of regioselectivity of heterocyclization reactions for aminoisoindole derivatives have been established. The conditions for the reaction selectivity between heterocyclic amidines and fluorine-containing enones were found. New methods of synthesis of artificial analogues of the natural alkaloid of anabazine have been developed, based on the obtained compounds of pyridine-containing amino acids. 3-hydroxyflavone derivatives were synthesized with cationic and zwitterionic substituents at the 4 'position of the chromonic nucleus. Product Description popup.authors Egorova Tetyana V. Biitseva Angelina V. Bugera Oleksandra I. Voitenko Zoia V. Kysil Аndriy І. Krykun Serhii O. Levkov Igor V. Lyubchuk Tetyana V. Zapko Magdalina D. Shylin Sergiy V. popup.nrat_date 2020-04-02 Close