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Information × Registration Number 0220U101509, 0119U100724 , R & D reports Title Synthesis of N,O,S-containing heterocycles using new catalytic systems. An experimental and theoretical study popup.stage_title Head Okovyty Serhii I., Доктор хімічних наук Registration Date 12-02-2020 Organization Oles Honchar Dnipro National University popup.description2  Object of study - synthesis of new ansambles of N,O,S-heterocycles, which include different combinations of aziridines, pyrrolidines, piperidines, pyranes, 1,3-oxazolidines, 1,3-oxazolidin-2-ones, triazinoquinazolines, morpholines and their carbonyl-containing analogs, as well as 5-6 membered cyclic sulfones. The purpose of the work is the development of practically important catalytic methodologies for the synthesis of N,O,S-heterocyclic compounds in the reactions of C-H activation, aziridination of allenes and related systems, 1,3-dipolar cycloaddition, as well as multicomponent cyclocondensations of β-ketosulfones. Methods of study - spectral (IR-spectroscopy, 1H and 13C NMR spectroscopy, mass spectrometry), quantum-chemical, X-ray diffraction analysis. It has been shown for the first time that the reactions of vinyl nucleophilic substitution of deuterium-labeled bicyclic methylenaziridines with vinylmagnesium bromide and lithium dimethylcuprate proceed according to the stereochemistry of the SNVπ mechanism. The method of synthesis of methylenaziridine ureas by the aminolysis of 6-methylene-3-oxa-1-azabicyclo[3.1.0]hexane-2-ones is proposed. Conditions for expansion of 3-oxa-1-azabicyclo[3.1.0]hexane-2-ones to monocyclic 5,6-dihydro-2H-1,3-oxazin-2-ones were found. The methodology for the synthesis of new N,O,S-heterocycles (derivatives of cyclic β-ketosulfones, pyrrolidines, etc.) has been improved through the development of new catalytic systems based on organocatalysts and transition metal compounds. The results obtained can be used to create new drugs with valuable properties, as well as to solve a number of problems of theoretical and experimental organic chemistry. Areas of application: synthetic organic chemistry, pharmaceutical chemistry, agriculture. Product Description popup.authors Kovalenko Valerii S. Lykholat Yurii V. Palchykov Vitalii O. Fedenko Vladimir S. Khromykh Nina O. popup.nrat_date 2020-04-02 Close