Registration Number
0220U101604,
0117U004269
, R & D reports
Title
To study the effectiveness of biopolymer (biodegradable, bioindeuctive) materials in the regeneration of the dura mater and associated cellular and tissue reactions in experimental traumatic brain injury.
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Head
Pedachenko Yevhen H.,
Registration Date
14-02-2020
Organization
The State institution "Romodanov neurosurgery institute, National academy of medical sciences of Ukraine"
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Biopolymers, bioresorbtion, substitute of tmo, collagen, chitosan, gelatine, polyetyloxide (peo), infrastructure spectroscopy. The purpose of the work is to establish the features and regularities of cell-tissue responses of TMO regeneration in the application of artificial membranes at experimental TBI for theoretical refinement and substantiation of criteria.Research methods - experimental, versatile morphological (histological, electron microscopy), physical (infrared spectroscopy), chemical, statistical. The work deals with a topical topic in neurosurgery - plastics of the dura mater. Effective plastics have two main functions: to create conditions for the tightness of the TMO closure and to reduce the likelihood of adhesion between the TMF substitute and the cerebral cortex.Advantages of artificial biodegradable materials (materials that are absorbed in the body) when choosing a plastic material in their ability to serve for fibroblasts frame to form a similar TMO tissue. To reduce the formation of fissures between the soft tissues of the skull and the dura mater or a TMO substitute, the use of additional plastic material is especially useful in decompression of the skull to facilitate further bone defect plasticity.The work deals with macrovisual, histological, molecular research (infrared spectroscopy) on comparative evaluation of collagen, chitosan TM substitutes, application of gelatin film for the prevention of adhesions between soft tissues of the skull and TMO or its substitute.
Product Description
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Vaslovich Victoria V.
Velichko Olga M.
Hnatyuk Olena P.
Gridina Nina Ya.
Dovbeshko Galina I.
Kadzhaia Mykola V.
Kozakevich Roman B.
Tatiana Malysheva Tatiana Malysheva Andriivna
Morozov Anatoly M.
Panteleychuk Andriy B.
Pedachenko Eugenіj G.
Сhernenko Oksana G.
Shmeleva Anna A.
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2020-04-02
