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Information × Registration Number 0220U101623, 0115U002949 , R & D reports Title The study of the regulatory functions of b - and a-catenin in age and patological reconstruction of the adult myocardium to the needs of personalized medicine and the development of modern methods of prevention, disease diagnosis and treatment of heart diseases popup.stage_title Head Piven Oksana O., Кандидат біологічних наук Registration Date 17-02-2020 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 During the reporting period, the signaling function of β- and α-E-catenin during age-related myocardial changes was analyzed. Overall, our data indicate the importance of signaling and adhesive function of the β- and α-E-catenin genes in age-related myocardial changes, since abnormal expression of fetal genes (ANP, BNP, α-MHC and β-MHC) was observed in mutant animals. activities of other important cardiac signaling systems (Pi3K / Akt, MEK1-Erk1 / 2, and cAMP / PKA). In addition, massive disturbances of cardiac metabolism have been shown in such animals, namely disorders of lipolysis and lipogenesis. The involvement of β-catenin in cardiac metabolism has been studied in detail, its effect on maintaining balance of function and mitochondrial function and biogenesis has been shown, which makes it possible to consider β-catenin as a potential target for therapy in metabolic disorders of the myocardium. Product Description popup.authors Balatskyi Volodymyr V. Boriachuk Olena O. Macewicz Larysa L. Papuga Alexander Ye. Ruban Tatiana P. popup.nrat_date 2020-04-02 Close