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Registration Number

0220U101623, 0115U002949 , R & D reports

Title

The study of the regulatory functions of b - and a-catenin in age and patological reconstruction of the adult myocardium to the needs of personalized medicine and the development of modern methods of prevention, disease diagnosis and treatment of heart diseases

Head

Piven Oksana O., Кандидат біологічних наук

Registration Date

17-02-2020

Organization

Institute of Molecular Biology and Genetics of NAS of Ukraine

Description

During the reporting period, the signaling function of β- and α-E-catenin during age-related myocardial changes was analyzed. Overall, our data indicate the importance of signaling and adhesive function of the β- and α-E-catenin genes in age-related myocardial changes, since abnormal expression of fetal genes (ANP, BNP, α-MHC and β-MHC) was observed in mutant animals. activities of other important cardiac signaling systems (Pi3K / Akt, MEK1-Erk1 / 2, and cAMP / PKA). In addition, massive disturbances of cardiac metabolism have been shown in such animals, namely disorders of lipolysis and lipogenesis. The involvement of β-catenin in cardiac metabolism has been studied in detail, its effect on maintaining balance of function and mitochondrial function and biogenesis has been shown, which makes it possible to consider β-catenin as a potential target for therapy in metabolic disorders of the myocardium.

Product Description

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Balatskyi Volodymyr V.
Boriachuk Olena O.
Macewicz Larysa L.
Papuga Alexander Ye.
Ruban Tatiana P.