Registration Number
0220U101667,
0118U005470
, R & D reports
Title
Investigation of functional plasticity of macrophages under the conditions of application of means of chemo- and biotherapy of cancer
popup.stage_title
Head
Didenko Gennadii V., Кандидат біологічних наук
Registration Date
17-02-2020
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine
popup.description2
It was shown that Ehrlich carcinoma growth induced significant shifts in the blood formula due to the changes in the different blood cells populations. On day 7 after the tumor transplantation, the absolute number of lymphocytes and monocytes increased; on the terminal stages, their number decreased while the number of granulocytes rose.
The functional state evaluation (cytotoxic and metabolic activities, NO production, and arginase activity) of macrophages, isolated from different bioniches during the growth of Ehrlich carcinoma, revealed that these cells progressively polarized from M1 phenotype (early after the tumor transplantation) towards M2 one (on the terminal stages). The obtained results open prospects for pursuit of new ways of applying the macrophages plasticity phenomenon in the cancer immunosurveillance reinforcement.
Product Description
popup.authors
Ivanchenko Alina V.
Voeykova Iryna M.
Didenko Gennadii V.
Kruts Olena O.
Symchych Tetiana V.
Fedosova Nataliia I.
Cheremshenko Nadiia L.
popup.nrat_date
2020-04-02
