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Information × Registration Number 0220U101692, 0118U007350 , R & D reports Title Investigation of mechanisms of neuroprotection in conditions of modeling of pathological states of the nervous system popup.stage_title Head Skibo Galyna G., Доктор медичних наук Registration Date 18-02-2020 Organization Bogomolets Institute of Physiology popup.description2  The technology to produce 3D transplant based on carbomer hydrogel 974P and populated with multipotent mesenchymal stromal cells, has been developed. For further in vitro studies and transplantation in vivo there were selected optimal concentration of cells and the method of their colonization of hydrogel. A model of focal cerebral ischemia in rats was developed using an intravascular occluder, the optimal time of ischemia (60 min) and reperfusion (72 h) duration were determined. The data will be used in further study the neuroprotective effects of drugs in ischemic brain injury. The effect of stimulation of nerve cells by low direct current in in vitro experiments using long-term cultures of dissociated hippocampal cells was investigated. Weak PS was found to reduce LPS-induced destructive changes in hippocampal culture. Morphological studies of the CA1 area of the hippocampus in ApoE-deficient mice were conducted under the conditions of consumption of low- and high-fat diets. It was found that the morpho-functional state of nerve cells in ApoE - / - mouse hippocampus depended significantly on fat content in diet. Studies have been conducted to improve the rotenone model of hemiparkinsonism Search for quantitative parameters which allow estimating the level of rotenone-dependent degeneration of dopaminergic neurons and the response of glial cells was performed. Software has been developed to identify degenerating cells by the criteria of their nucleus structure. Product Description popup.authors Kovalenko Tetyana М. Lushnikova Iryna V. Man'kivska Olena P. Osadchenko Iryna O. Pacseva Marina A. Savchuk Olena I. Skybo Galyna G. Tsupykov Oleg M. Chayka Nataliya V. Yatsenko Katerina V. popup.nrat_date 2020-04-02 Close