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Registration Number

0220U101744, 0118U005466 , R & D reports

Title

Determination of predictors of peripheral blood lymphocyte radiosensitivity of patients with endometrial cancer in vitro and the effects of protector ex vivo

Head

Domina Emiliia A.,

Registration Date

19-02-2020

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Description

 The linear nature of radiation-induced biochemical damage during test irradiation of blood in the range of investigated doses is revealed. Potential predictors of donor radiosensitivity were identified. Metformin has been shown to inhibit free radical processes, accelerate the proliferation and apoptosis of irradiated lymphocytes. It was shown that with increasing radiation dose, the level of stable aberrations of chromosome-3 increases, the structural alterations of which are associated with high carcinogenic risk. It is shown that the predictors of radiosensitivity of peripheral blood lymphocytes of conditionally healthy persons are indicators of oxidative metabolism (pro-antioxidant ratio, malonic dialdehyde level, and superoxide generation rate), genetic instability (chromosomal exchange type aberrations) and apoptosis. Metformin has been found to modify the intensity of free radical processes, accelerate the proliferation of PBL, promote premature emergence of aberrant II-III mitosis cells and enhance apoptosis.

Product Description

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Glavin Olexii A.
Grinchenko Olga O.
Druzhyna Mykola О.
Domina Emiliia A.
Makovetska Lyudmyla I.
Mikhailenko Viktor M.