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Information × Registration Number 0220U101819, 0119U002038 , R & D reports Title The Use Of The Luminescent Method For The Study Of The Interaction Of Proteins With Certain Drugs. popup.stage_title Head Antonovych Valeriy P., Доктор хімічних наук Registration Date 26-02-2020 Organization Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine popup.description2 Object of study - medicinal substances (MS), human serum albumin. The subject of the study is to determine the binding parameters of some MSs to human serum albumin by quenching luminescence. Research methods - spectrophotometry, fluorescence spectroscopy. The basic idea of the work was to extend the capabilities of the luminescent method of analysis to determine the binding of some medicinal substances to human serum albumin (HSA). It was necessary to establish the interaction of some drugs with HSA and to determine the binding parameters: constants, the number of binding sites and the distance between the donor (HSA) and the acceptor (MS); and to develop highly sensitive methods for the determination of residual quantities of propoxazepam from the surfaces of pharmaceutical equipment.   Product Description popup.authors Yegorova Alla V. Antonovich Valerij P. Dekhtiarenko Olga M. Dotsenko Volodymir P. Maltsev Heorhii V. Skrypynets Yuliia V. popup.nrat_date 2020-04-02 Close