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Information × Registration Number 0220U102122, 0117U001418 , R & D reports Title Informative biomarkers of some disturbances at Parkinson's disease and their effects on the phenotype, disease prognosis and life quality of patients popup.stage_title Head Karaban Iryna M, Доктор медичних наук Registration Date 09-03-2020 Organization State institution "D. F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine" popup.description2 185 patients with middle-aged and elderly Parkinson's disease (94 women and 91 people) were examined.The mean cognitive status score on the MMSE scale in the middle-aged group was 28.7±1.8 points, in the elderly group it was statistically lower and was 25.8±3.8 points (p<0.05).In the elderly group, the incidence of cognitive impairment at the stage of LKR outweighed that of the middle-aged group and was 30.12% (n=25) and 26.06% (n=18), respectively.The rates of cognitive impairment at the PKR stage - 34.94% (n=29) and WRC - 24.10% (n=20) were predominant in the elderly group, whereas in the middle age group these indicators were 28.36% (n=19) and 1.50% (n=1), respectively (p<0.05), indicating a higher degree of cognitive deficits in the clinical picture of the disease in elderly patients.The absence of cognitive impairment was more prevalent in the middle-aged group of 43.28% (n=29) compared to the elderly group of 10.84% (n=9) (p<0.05). When assessing age correlations, neurocognitive examinations (MMSE, MoCA, and FAB scales) and KVP parameters to determine Spearman's rank correlation coefficient, a clear relationship between the MMSE, MOSA, FAB, and age scales was established.The MMSE correlation coefficient with the patient's age at the time of the examination was shown to be r=-0.63 (p<0.05), on a MoCA scale r=-0.49 (p<0.05) and FAB r=-0.46 (p<0.05), which can be regarded as a strong negative relationship.The possibility of using a cholinesterase inhibitor in patients with Parkinson's disease with cognitive impairment is substantiated.It was found that after the course,3 months, the reception of Rivastigmine there was a statistically significant improvement.The results of a comprehensive analysis of the effect of course administration of rivastigmine on the cognitive function of patients with CP, will recommend the inclusion of the drug in the complex pathogenetic therapy of dementia associated withCP, which is based on neurodynamic and regulatory disorders under Product Description popup.authors Gasyuk Tetyana V Karasevich Nina V Kryzhanovsky Sergiy A Melnik N. Rozhkova Zinaida Z popup.nrat_date 2020-04-02 Close