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Registration Number

0220U102185, 0118U001611 , R & D reports

Title

To study structural-functional changes of elements of the chorioretinal complex of eyes of rats caused by a mixture of alcohols (40% methanol solution and 100% methanol

Head

Молчанюк Наталія Іванівна,

Registration Date

10-03-2020

Organization

State Institution "The Filatov Institute of Eye Disease and Tissue Therapy of NAMS of Ukraine"

Description

 Results. It has been shown that endothelial cells (EC) of XO vessels, PES cells and SMC, which are located under the outer boundary membrane, were found to be the most sensitive structures to the toxic effect of the alcohol mixture at both methanol doses. Depth of pathological changes in these structures depended on the methanol dose. Significant destructive changes in them were noted after 1 hour and 10 minutes of observation. In the retina, the most significant changes were in PES cells. In the dynamics of the study (up to 3 months) in the structures of the CRC revealed both pathological changes and signs of compensatory-restorative processes. The signs of the restorative nature of the cells under study were manifested more after the introduction of a mixture of alcohols with a methanol dose of 2.5 g/kg of body weight. Leading place in the development of pathological changes in the investigated structures of CRC after conducting a mixture of alcohols with a dose of methanol of 0.75 g/kg and a dose of 2.5 g/kg of body weight of rats, methanol is given. The primary destructive processes in CRC, after administration as a mixture of alcohols, regardless of the methanol doses used, begin in the EC vessels of the choroid.

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Boyko Nadiia O
Volkova Liudmyla F
Gavronska Natalia M.
Hutnyk Viktor M
Molchaniuk Nataliia I.
Shved Ganna V