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Registration Number

0220U102442, 0115U000657 , R & D reports

Title

The complex diagnostic and predictive algorithms of subarahnoidal'nyh hemorrhage in patients of different age group.

Head

Buchakchyiska Nataliia M,

Registration Date

13-03-2020

Organization

State Institution “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”

Description

A comprehensive examination of 109 patients of 87 patients with SAH of aneurysmal and spontaneous etiology was performed. The clinical characteristics, the characteristics of the SAH course, the dynamics of neurological scales results and the structure of complications in patients hospitalized for SAH of nontraumatic etiology were investigated. Expressiveness and direction of pathological changes that determine the characteristics of the SAH course in subjects of different age groups were evaluated. The use of the generalizing classification scale Ogilvy & Carter in the framework of the prediction of the SAH course in solving the question of patient management tactics at different stages of the disease has been finalized and clinically tested. The structure of risk factors prevalence for development of non-traumatic genesis in SAH patients was studied. The associative pathophysiological relationships between the expressiveness of neuroendocrine biomarker copeptin metabolic disorders and hyponatremia in patients with SAH of varying severity were evaluated. A fundamentally new important clinical and prognostic value of the copeptin as an universal diagnostic marker of the severe condition of patients in the acute period of SAH and a parameter that is reliably associated with the complications formation, primarily secondary ischemia, hydrocephalus and cerebral vasospasm, is shown. The concept of the pathogenetic role of osmotic degeneration in patients with SAH of aneurysmal and spontaneous genesis has been formed and generalized. New prognostic value is proven for predictors of unsatisfactory clinical efficacy of therapy and the development of persistent neurological disorders / disability at SAH.

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Bakhareva Larysa V
Kravchenko Olena O
Kutsak Andrey V
Maramukha Ihor V
Maramukha Volodymyr I
Polkovnikova Kseniya Yu