Registration Number
0220U102479,
0117U000658
, R & D reports
Title
HSP70/HIF-1a-mediated mechanisms of endogenous neuroproection : development of approaches to its pharmacological regulation.
popup.stage_title
Head
Byelenichev Ihor F., Доктор біологічних наук
Registration Date
16-03-2020
Organization
Zaporizhzhya State Medical University
popup.description2
It was first established that in vitro modeling of hypoxia in a suspension of neurons led to an increase in free radical oxidation, a shift of the thiol-disulfide equilibrium toward oxidized thiols (a sharp decrease in the pool of reduced glutathione due to the increase in its oxidized form); investigated that pathobiochemical disorders in the suspension of brain neurons of rats with acute cerebral ischemia proceeded against the background of changes in the expression of factors of endogenous cytoprotection - HIF and HSP proteins; investigated that the most sensitive to ischemic injury is the hippocampal zone, which, as a result of acute impaired cerebral circulation (BPMC), decreases the level of HSP70 and significantly increases the concentration of the nitrosating stress marker nitrotyrosine in the cytosolic fraction of the cytosolic fraction.
In vitro experiments it was determined that GPMC is accompanied by the development of nitrosating stress, which damages the main brain structures, resulting in neurological deficiency and the survival of experimental animals significantly decreases
Product Description
popup.authors
Yehorov Artem A
Aliieva Olena H
Bila Yuliia V
Bak Pavlo H
Bukhtiiarova Nina V
Zidrashko Halyna A
Zavhorodnia Maryna I
Kamyshnyi Oleksandr M
Korostina Khrystyna I
Nosach Svitlana H
Popazova Olena O
Ryzhenko Viktor P
Samura Iryna B
Tykhonovskyi Oleksandr V
popup.nrat_date
2020-04-01
