Search academic texts

Information × Registration Number 0220U102526, 0118U004370 , R & D reports Title Purposeful search of anti-inflammatory agents among condensed and spiro-condensed quinazoline derivatives popup.stage_title Head Kovalenko Sergiy I, Доктор фармацевтичних наук Registration Date 17-03-2020 Organization Zaporizhzhya State Medical University popup.description2 Generalization and detailed analysis of the results of studies on pro-inflammatory activity of synthesized compounds in vivo were performed, which allowed to establish certain correlations in the series "structure - biological effect". Among other things, it has been found that the presence of a triazine moiety and a carboxyethyl residue is critical for the manifestation of anti-inflammatory action. It has also been found that the modification of compounds containing a carboxyl group by the formation of their salts makes it possible to change the light-processing characteristics, but has almost no effect on the severity of the anti-inflammatory action. Product Description popup.authors Antypenko Olena M Voskoboinik Oleksii Yu Krasovska Nataliia I Martynenko Yuliia V Moskalenko Oleksandra S Nosulenko Inna S Stavytskyi Viktor V Kholodniak Olena V Kholodniak Serhii V Shabelnyk Kostiantyn P popup.nrat_date 2020-04-01 Close