Search academic texts

Information × Registration Number 0220U102598, 0119U000579 , R & D reports Title Identify ways to reduce the disability of patients with giant cell disease of bones on the basis of targeted therapy and optimization of surgical treatment popup.stage_title Head Diedkov Anatolii H., Registration Date 09-04-2020 Organization National Cancer Institute popup.description2  A retrospective cohort of patients with PCD was investigated, comprising 103 patients who have been observed for at least three years. Complete radical resection of the prosthesis was performed in 64 patients, of which 43 cases of bone resections forming the knee joint, and 19 - other localizations, and in the group of patients who underwent "conservative" surgical treatment in the volume of tumor exochleation and 59 plastic defects. The number of local recurrences in the group of radical surgical treatment - 4 (6.7%), and in the group of "conservative" surgical treatment – 19 (29.6%), which indicates a significantly higher rate of local recurrence in the "conservative surgery" group (p = 0.048). The number of recurrent surgical interventions for complications: 11 (17.7%) and 4 (6.8%) cases, which indicates a significantly (p = 0.05) higher risk of complications in the group with prosthesis. The average MSTS score in the endoprosthetic group was 53.3% (95% CI 26.6% –86.6%), and the conservative surgery group 74.2% (95% CI 66.6% - 93.3%). The functional results of the operated limb on the MSTS scale were significantly (p = 0.062) higher in the "conservative" surgery group. The scheme of combined treatment of patients with HCP with the use of neoadjuvant targeted therapy and emergency ("conservative") surgery was developed, which involves subcutaneous administration of denosumab at a dose of 120 mg for patients with histologically verified HCP at 1-8-15-28 day of the first month of therapy every 28 days. SCTA control of the primary lesion is performed after the sixth administration of denosumab with subsequent planning for the type of surgery. 17 patients were treated according to the developed methods. Product Description popup.authors Boichuk Serhii I. Diedkov Anatolii H. Kostiuk Viktor Yu. Maksymenko Bohdan V. popup.nrat_date 2020-07-03 Close